330 North Wabash, previously known as IBM Plaza and IBM Building, and now renamed AMA Plaza, is a skyscraper situated in downtown Chicago, Illinois, USA, at 330 N. Wabash Avenue. It was designed by the renowned architect Ludwig Mies van der Rohe, although he passed away in 1969 before construction commenced. In the building's lobby, you can find a small bust of the architect created by sculptor Marino Marini. This 52-story structure overlooks the Chicago River and stands at a height of 695 feet (212 meters). Notably, 330 North Wabash is the second-tallest building designed by Mies van der Rohe, with the tallest being the Toronto-Dominion Bank Tower at the Toronto-Dominion Centre. This skyscraper marked Mies van der Rohe's final architectural contribution in the United States.

The original corporate occupant, IBM, no longer owns the building or maintains offices within it. In 1996, IBM sold IBM Plaza to the Blackstone Group. IBM gradually vacated IBM Plaza, with the transition primarily taking place in early 2006 when they relocated to the Hyatt Center, situated closer to Union Station. The current primary tenants of the building include the American Medical Association, Langham Chicago (managed by Langham Hotels International), WeWork, and the law firm Latham & Watkins.

IBM Plaza, now known as AMA Plaza, boasts several distinctive design elements that were unusual for an office building, but they catered to the needs of its original owner. The building features robust electrical and environmental systems, robust floor strength, and varying ceiling heights on specific floors, which can support substantial raised floor computing centers. Given the importance of fire safety, especially with IBM's substantial workforce, asbestos was used as a key fire prevention material during that period. As with many buildings from that era, asbestos removal and management continue to be part of the building's maintenance, with ongoing air quality monitoring and asbestos removal when necessary. Additionally, the building features an advanced "banked" intelligent passenger elevator system, including separate all-floor cargo elevators, which effectively serves the building's size and minimizes waiting times. Notably, IBM Plaza remained unaffected during the 1992 Chicago Flood.

In 2007, plans were unveiled to transform the building's second through thirteenth floors into a high-end hotel. The Langham, Chicago, which opened its doors in 2013, occupies these floors. The Langham Hotel within the building earned the title of the best hotel in the United States by US News in 2017. On February 6, 2008, the building was designated as a Chicago Landmark and subsequently added to the National Register of Historic Places on March 26, 2010. It holds the distinction of being the newest building in Chicago to feature on both of these prestigious lists.

Furthermore, on December 9, 2011, the American Medical Association made an announcement regarding its headquarters and workforce relocation to 330 N. Wabash from its previous location on State Street. This relocation was completed in September 2013, and the building was renamed AMA Plaza.

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